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The exception is if you experience signs of a systemic allergic reaction (hives spreading beyond the injection site, breathing difficulty, facial swelling), which requires immediate medical evaluation before continuing

A meta-analysis covering over 28,000 patients found that while the overall rate of GI adverse events was similar (approximately 5253% of patients in both groups), serious adverse events occurred somewhat more frequently with higher tirzepatide doses (5.37% at 1015 mg) compared to semaglutide (2.8%)

This does not automatically indicate a problem

(25% of body weight), compared to 1.5% on placebo, according to data not controlled for type 1 error