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In addition to either the semaglutide or placebo, participants received lifestyle intervention except for those who were part of the STEP 3 group

When faced with a reduced probability of robust -cell function as encountered in diabetes of long duration, if significant weight loss and maintenance can be achieved, insulin sensitivity can be restored and the strain upon an already compromised -cell can be lifted

It makes fats in the blood better, lowers blood pressure, and helps control sugar levels

Side effects are similar since both contain semaglutide

The observational literature was heterogeneous and predominantly retrospective

Over the full study period, the average difference between orforglipron and placebo was 0.9 kg among those switching from semaglutide