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After that, if tolerated and under the supervision of your prescriber, the dose can be slowly increased up to 2.4 mg once a week

Hjerpsted JB, Flint A, Brooks A, Axelsen MB, Kvist T, Blundell J

A large-scale observational study published in 2023 analyzed electronic health records of over 80,000 patients with obesity and found that those prescribed semaglutide had a 50-56% lower risk of alcohol use disorder compared to those on other obesity medications

23 Adverse reactions and tolerability: The DPP-4 inhibitor class of medications is generally very well tolerated, although post-marketing reports have described serious adverse events (see Warnings and precautions section)

doi:10.3389/fphar.2022.806470

This work was eventually published in the JBC journal in August 1991