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what does glp-1 actually do Agonists - is it? glp-1_analogs [TUSOM | Pharmwiki]
Description
After 4 weeks on LDN, we can increase it to 4.5mg if required
![what does glp-1 actually do Agonists - is it? glp-1_analogs [TUSOM | Pharmwiki]](https://tmedweb.tulane.edu/pharmwiki/lib/exe/fetch.php/glp1.png?w=600&tok=baf39c)
But the weight itself tends to return
![what does glp-1 actually do Agonists - is it? glp-1_analogs [TUSOM | Pharmwiki]](https://www.frontiersin.org/files/Articles/1085799/xml-images/fendo-14-1085799-g001.webp)
95% CI, -0.02 to 0.03
![what does glp-1 actually do Agonists - is it? glp-1_analogs [TUSOM | Pharmwiki]](https://www.c2st.org/wp-content/uploads/2026/01/GLP1Blog.png)
Even more impressively, during the SURMOUNT-1 trial, study volunteers who used the highest dose (15mg) of tirzepatide lost as much as 21% of their body weight-equivalent to an average of 52 pounds
![what does glp-1 actually do Agonists - is it? glp-1_analogs [TUSOM | Pharmwiki]](https://openmedscience.com/wp-content/uploads/2025/07/GLP-1-is-more-than-just-a-weight-loss-aid.jpg)
This allows treatment plans to remain aligned with patient response while maintaining safety considerations
![what does glp-1 actually do Agonists - is it? glp-1_analogs [TUSOM | Pharmwiki]](https://assets.nutrisense.io/62e18da95149ec2ee0d87b5b/64391424d27b10fed6c2a704_2-what-do-glp-1-agonists-do-in-the-body.webp)
Novo Nordisk's CagriSema, targeting over 20% weight loss, and Eli Lilly's retatrutide, showing a 24% weight reduction in early trials, are notable candidates
![what does glp-1 actually do Agonists - is it? glp-1_analogs [TUSOM | Pharmwiki]](https://cdn.shopify.com/s/files/1/0606/7313/0669/files/How_GLP-1_Works_3ad82564-c868-43c4-b818-e4693aa67399.jpg?v=1746764346)