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placebo, n=27,709)

Low testosterone may result in a loss of confidence and lack of motivation

Specifically, chronic exposure to high fat diet promotes proliferation of K cells, thus resulting in increased GIP synthesis

de Candia P, Spinetti G, Specchia C, Sangalli E, La Sala L, Uccellatore A, Lupini S, Genovese S, Matarese G, Ceriello A

Efficacy end points will be analyzed using data obtained during the treatment period from all randomized participants exposed to at least one treatment dose (modified intentiontotreat [mITT] population)

In the Phase 2 clinical trial published in the New England Journal of Medicine (2023), participants receiving the highest dose of retatrutide reported an average body-weight reduction of about 24% at 48 weeks