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Most cases result from dehydration caused by the medication's gastrointestinal effectsparticularly nausea, vomiting, and diarrhoeawhich lead to concentrated urine appearing darker in colour

Weeks 17 onward: 12mg weekly maintenance for those in the highest arm

Protective effect of metformin against thyroid cancer development: a population-based study in Korea

However, emerging research and case reports support the biological plausibility of these changes

Nevertheless, GLP-1 analogues, while improving blood flow in pathology-affected tissues, may also have side effects, for example, on the pancreas and gastrointestinal tract