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The investigation began in 2023 when Mass Eye and Ear neuro-ophthalmologists noticed that three patients in their practice had been diagnosed with the relatively uncommon disease in just one week.
Research published in Neuroscience Applied in 2024 demonstrated that semaglutide reduces appetite while simultaneously increasing dopamine reward signalling in the ventral tegmental area a key node in the brain's reward circuitry

The line chart shows us that from 2020 onward, the unit cost trend for behavioral health spiked to 2023 from about $100 to $125m and that behavioral health claims as a percent of all medical claims more than doubled between 2018 to the third quarter of 2023
