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The triple-incretin pharmacology represents an attempt to combine the insulin-sensitizing and appetite-modulating effects of GLP-1/GIP agonism with the energy-expenditure effects of glucagon receptor activation

Still in clinical trials, this triple agonist has shown remarkable results in early studies

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[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Harasta AE, et al

For example, one might speculate that improving mitochondrial health with MOTS-c could enhance cellular responsiveness, potentially amplifying the effects of Retatrutide on glucose uptake or energy expenditure

While stopping abruptly isn't dangerous medically, a gradual taper often produces fewer rebound symptoms and better long-term results