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Some researchers believe the GIP receptor activation in multi-agonist medications like Retatrutide and Tirzepatide may provide protective effects against some gastrointestinal side effects

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July 2024: A study published in JAMA Ophthalmology suggests that Ozempic users could be at higher risk of NAION, a condition that can cause sudden and permanent vision loss

Retatrutide adds a third pathway through glucagon receptor activity

Both contain semaglutide, but Rybelsus is taken orally, while Ozempic is injected weekly
