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Hicks, B

Abstract Individuals with diabetes often have chronic inflammation and high levels of inflammatory cytokines, leading to insulin resistance and complications

This permits once-daily dosing, which maintains adequate plasma concentrations over a 24-hour period [31]

Within its N-terminal domain, GLP-1R contains six conserved cysteine residues that form specific disulfide bonds between Cys46-Cys71, Cys62-Cys104, and Cys85-Cys126 [30]