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Rapid weight loss itselfindependent of medicationcan stress the skin by reducing subcutaneous fat and altering skin turgor and barrier function

Sieminski and Zemojtel previously published a case report concerning a 32-year-old woman with migraine who experienced RLS symptoms after receiving IV metoclopramide for migraine-associated vomiting

They are prepared by state-licensed compounding pharmacies

Zhou, M.C

However, dose-dependent gastrointestinal effects limit efficacy, so drugs with GLP-1 and GCG pharmacology can also target alternative pathways and may expand the therapeutic index (132)

These effects are in direct response to the presence of carbohydrate in the gut and therefore the chance of significant hypoglycemia occurring is unlikely, unless used in combination with other hypoglycemic drugs