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In comparison with naturally occurring receptor ligands, retatrutide has lower potency at the human glucagon and GLP-1 receptors, at approximately 0.3- and 0.4-fold, respectively, while showing markedly greater potency at the human GIP receptor, at about 8.9-fold

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Boulay said these days, one question she often gets from patients is, Do we need bariatric surgery now that there are effective GLP-1 medications such as Ozempic and Zepbound? Some patients, especially lower BMI patients (less than 35) with diabetes, would likely get more benefit out of a GLP-1 than surgery, she said

Current Regulatory Status in the UK Retatrutide is not approved by the MHRA or EMA and is unavailable as a licensed medicine in the UK

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doi: 10.1186/s12889-018-5114-5