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Interestingly, semaglutide probably plays a role in plaque vulnerability, since the gene expression of proteins involved in extracellular matrix turnover (MMP-3 and MMP-13) and plaque hemorrhage (CD163) was reduced in the semaglutide-treated group [60]

The most commonly reported adverse effects in Phase 2 trials were gastrointestinal in nature, including: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent and most pronounced during dose escalation, typically improving over time

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Official guidance from professional organizations often reflects the best consensus on evidence interpretation

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This guide breaks down every approved injection site for tirzepatide, explains exactly how to use each one, covers rotation strategies that prevent complications, and addresses the real questions people have after their first few weeks on this GLP-1/GIP receptor agonist