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These are the same patterns reported in early tirzepatide tolerance research , and they typically resolve without intervention

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Notably, 72% of participants with prediabetes at baseline reverted to normoglycemia during Retatrutide treatment, indicating potential for diabetes prevention in at-risk populations

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Although leave-one-out and Baujat analyses were performed, they did not meaningfully reduce heterogeneity, indicating that the variability is intrinsic to the studies themselves

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Dietary considerations may also prove beneficial

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