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An emphasis was placed on post-marketing surveillance informed by pre-marketing safety signals and on comorbid conditions that are common in T2DM patients, including: cardiovascular disease, chronic kidney disease, and older age

Therefore, decreased DPP-4 activity is unlikely to explain the elevated GLP-1 levels after metformin treatment

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and those who want to avoid needles and side effects like nausea and indigestion

3A), but a significant interaction between time and group was not observed

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas