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Part XI: Technology Roadmap Next-Generation Molecules and the New Exclusivity Frontier New Modalities, New IP Architectures The pharmaceutical industrys shift toward novel therapeutic modalities, including mRNA therapeutics, siRNA/antisense oligonucleotides, cell and gene therapies, and antibody-drug conjugates (ADCs), is not merely a scientific development

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Subsequent studies introduced site-selective conjugation strategies to reduce product heterogeneity

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Their bodies may process medications differently, and they are more likely to experience side effects from drugs

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GLP-1 and GIP are gut-derived incretin hormones that augment glucose-stimulated insulin secretion and have been shown to have important roles in weight regulation

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