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Weight loss may follow as the body adjusts to reduced calorie intake and improved metabolic signaling

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Supplementary information The online version contains supplementary material available at 10.1038/s41421-024-00700-0

Mechanistic sampling of intestinal tissue during this trial would best validate the reparative hypothesis if analyses include tight junction protein expression (e.g., claudins, occludin, zonula occludens-1), histologic healing assessments using validated indices (e.g., Geboes score, Robarts Histopathology Index), and intestinal permeability assays such as the lactulose-mannitol ratio