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Nonfatal myocardial infarction occurred in 2.3% of patients treated with oral semaglutide and 1.9% treated with placebo (HR 1.18, 95% CI 0.731.90), nonfatal stroke occurred in 0.8% versus 1.0% treated with placebo (HR 0.74, 95% CI 0.351.57), and death from cardiovascular causes occurred in 0.9% versus 1.9% treated with placebo (HR 0.51, 95% CI 0.310.84)

The decision to continue or discontinue GLP-1 therapy should be made collaboratively between the patient and their healthcare team, weighing the metabolic benefits against the risk of recurrent biliary symptoms

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For example, the single-dose Zepbound pen and Zepbound vials are not included in the program