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Thus, although much research is focused on defining the direct intrakidney effects of GLP-1 receptor agonists, it is possible that some of the benefits occur indirectly, as a result of GLP-1 receptor agonists ability to improve kidney risk factors, as well as via extrarenal systemic effects of these agents that are not yet fully defined, such as attenuation of low-grade systemic inflammation

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In this article, we intend to focus on GLP-1RAs in the context of neurodegenerative diseases using examples from Alzheimers disease (AD) and Parkinsons disease (PD), since there is a growing list of preclinical studies showing GLP-1RAs as potential disease-modifying agents in these disorders

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