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Tirzepatide is a novel, once-weekly, dual GIP and GLP-1 receptor agonist (twincretin) for the treatment of type 2 diabetes

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Retatrutide is a multi-receptor peptide agonist targeting GLP-1, GIP, and glucagon receptors, designed for advanced metabolic research

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Stopping semaglutide often triggers rapid weight regain within weeks to months as appetite hormones reset

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This review methodically argues for a theoretical paradigm shift

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