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Weight Loss (Obesity) Drug:Average weight loss Semaglutide:~1215% body weight Tirzepatide:~20% body weight Clinical trials show tirzepatide produced ~50 lbs weight loss vs ~33 lbs with semaglutide in some studies 3.Safety & Side Effects Common side effects for both: Nausea Vomiting Diarrhea Constipation Reduced appetite 4.Cardiovascular Benefits Semaglutide currently has stronger CV outcome data

Alternatives include Wegovy (for weight loss), Saxenda (liraglutide), Mounjaro (tirzepatide), or insulin for diabetes management

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Design, synthesis, and evaluation of a novel series of indole sulfonamide peroxisome proliferator activated receptor (PPAR) // triple activators: Discovery of lanifibranor, a new antifibrotic clinical candidate