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If you're taking a GLP-1 receptor agonist (semaglutide) or a dual GLP-1/GIP receptor agonist (tirzepatide) for weight management, the results are probably impressive

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The odds are good that you know someone who has taken a GLP-1 or other weight loss medication

The GLP-1R is expressed in many tissues, including pancreatic islets, the central nervous system, lung, kidney, heart, intestine, and also on immune cells ( When secreted by L cells, GLP-1 either functions in an endocrine manner, being released into the blood stream where it is rapidly inactivated by DPP-4 with a half-life of about 2 min, or exerts paracrine effects like stimulating neurons

[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Kreidieh D., Itani L., El Masri D., Tannir H., Citarella R., El Ghoch M

Whether microdosing emerges as a meaningful addition to the metabolic toolkit remains to be seen