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The Authors reported that treatment with incretins significantly suppressed the FSH-induced synthesis of progesterone through the inhibition of the expression of progestogenic factors and enzymes, whereas there was no significant effect on oestrogen synthesis by rat granulosa cells, thus suggesting the possible role of GLP-1 RA in the treatment of dysregulated steroidogenesis in PCOS [43]

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Demonstrating a direct, weight-independent hepatic effectparticularly mediated through LSECsadds an entirely new layer of biological plausibility and therapeutic relevance
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