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Most published studies to date are exploratory in nature, characterized by modest sample sizes, short follow-up durations, and considerable variation in patient selection criteria

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An exercise therapy of at least 30 minutes a day was recommended

Research indicates that many addictive substances acutely increase dopamine signaling, although addiction also involves broader neurochemical, stress, learning, genetic, and environmental mechanisms

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Detailed information regarding drug exposure and drug treatment indication, including dose, timing of therapy initiation, duration and concurrent medications, is also documented during the initial contact with the TIS