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Comparison of CT-388 (Roche/Carmot) and tirzepatide (Mounjaro/Zepbound), two dual GLP-1/GIP agonists with different signaling profiles, weight loss data, and development status.
Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node GLP-1 has direct chronotropic effects on the heart mediated by GLP-1 receptors in pacemaker cells of the sinus node, inducing changes in action potential morphology
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Clinical trials show an average loss of 15 percent body weight, though individual results vary based on starting weight, lifestyle habits, and how long you stay on the medication.
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