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Retatrutide is currently under investigation in a global phase 3 clinical trial programme, following promising results from its phase 2 study (NCT04881760) published in the New England Journal of Medicine in 2023

The injection delivers the drug straight under the skin, where its absorbed relatively efficiently into the bloodstream and can act steadily over many days

And BrightGene just earned a spot on that list

This introduces variability in pharmacodynamics, as GLP-1RA penetration into specific brain regions may differ based on sex, compound properties, and age ( This raises important questions for ongoing trials such as EVOKE, which may uncover sex-specific differences and justify subsequent investigations of GLP-1 analogues in female populations

If you have questions about medications or potential side effects, please speak with your healthcare provider

Semaglutide is an injectable weight-loss medication