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2025;8(1) doi: 10.1001/jamanetworkopen.2024.57349

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Interestingly, the combination of PIO with DAPA showed the biggest reductions of hepatic tissue inhibitor of metalloproteinase 1 (TIMP-1) concentrations

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The effects of overexpressing FXR were recovered by limiting miR-33 expression, demonstrating that FXR decreased GLP-1 secretion via boosting miR-33 expression and, by extension, GCG and CREB1 expression