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Importantly, the observed rise in the relative risk of new thyroid cancer diagnoses was limited to the first year after GLP-1RA initiation

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Findings suggest physiological GLP-1 signalling may induce its anorectic effects in man by indirectly activating central controllers of appetite through gastric and pancreatic receptors

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It is also approved to reduce the risk of cardiovascular events like heart attacks and stroke in adults with type 2 diabetes and heart disease