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Heart disease and stroke statistics2013 update: A report from the American Heart Association

*This study highlights semaglutides off-label used for obesity, driven by social media, and compares its safety profile to other GLP1 agonist, emphasizing the need for careful monitoring 8.Nesti L, Trico D

Bottom line: Oral GLP-1 is expanding the categorybut injections still set the performance standard

GLP-1 prescribing for clinical indications (type 2 diabetes, BMI 30, metabolic conditions) is included at all tiers

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It shares a high degree of sequence similarity in the TMD region with GLP-1R (61%) that has been studied extensively both structurally and functionally