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This effect appears to explain the carbohydrate stimulated ileal brake where plasma GLP-1 increases without a change in PYY (64)

Diabetes Care 35:12251231 Russell-Jones D, Cuddihy RM, Hanefeld M et al (2012) Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study

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Statements Author contributions XH: Conceptualization, Data curation, Formal Analysis, Methodology, Writingoriginal draft