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Zepbound, a popular weight loss drug, has become the first FDA-approved prescription medication to treat obstructive sleep apnea.

Single-cell RNA sequencing (scRNA seq) and in vitro studies revealed that tirzepatide up-regulated FOXO1, reactivating the FOXO1-PDX1/MAFA axis

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The dual action gives better glucose control and significant weight loss compared to older GLP-1 agonists alone

Most patients taking semaglutide see initial weight loss within the first four weeks, though results vary based on starting dose and individual metabolism
PSCs were isolated from male Wistar rats
