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In summary, constipation during pregnancy should first be treated with nonpharmacologic therapy

It includes tirzepatide injections (Mounjaro) a first in class long-acting dual glucose-dependent insulinotropic polypeptide GIP as well as once-daily semaglutide tablets (Rybelsus), the notification said

[16] The San Antonio Heart Study adds to this notion by demonstrating a 2- to 3-fold increase in mortality risk in subjects with diabetes or metabolic syndrome at baseline

Nissen, who serves as study co-chair of SURMOUNT-MMO, notes that the exclusion of patients with diabetes will avoid confounding of results by favorable outcomes due to tirzepatides antidiabetic effects

I also suggest the following approach to treating DED in patients taking GLP-1s: Long-term management I always let patients know that by taking a positive approach to preventive self-care by controlling their A1C, losing weight, and following a healthier diet with a GLP-1, theyre also helping their eyes