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Consequently, as discussed in a comprehensive review [152], a large portion of intestinal GLP-1 is already degraded in the capillaries of the distal gut with an estimated 25% of active GLP-1 reaching the liver and only 1015% reaching the general circulation [152,176,183,191]
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The popularity of prescription weight-loss injections has skyrocketed in recent years, with Semaglutide (Ozempic, Wegovy) and Tirzepatide (Mounjaro, Zepbound) leading the way
[DOI] [PubMed] [Google Scholar] 35.Sun EW, de Fontgalland D, Rabbitt P, Hollington P, Sposato L, et al
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