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In conclusion, compound 20 in the biphenyl-substituted triazole group, as well as compounds 21 and 22 in the acetoxy- and monophenyl-substituted triazole groups, demonstrated the highest potency for inhibiting DPP-4 (99) (Figure 4)
GLP-1 exerts its various functions by interacting with GLP-1R, which is a G protein-coupled receptor that is widely distributed in the pancreatic islets, GIT, lungs, kidneys, heart, and some regions of the central and peripheral nervous system
Glucagon-like peptide-1 receptor agonists compared with basal insulins for the treatment of type 2 diabetes mellitus: a systematic review and meta-analysis
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doi: 10.1007/s00125-009-1643-x 37 LiuGMaHQiuLLiLCaoYMaJet al
