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Dose adjustments or alternative management strategies may be necessary

Scar tissue may prevent the medication from absorbing into your body effectively

The lawsuits claim that stronger warnings could have changed prescribing decisions, patient monitoring, medication discontinuation, or the timing of medical intervention after early symptoms appeared

Ann Rheum Dis 72(7):11251135.10.1136/annrheumdis-2012-202745 [DOI] [PubMed] 44.Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, Towheed T, Welch V, Wells G, Tugwell P, American College of R (2012) American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee

Mulvihill EE, Varin EM, Gladanac B et al (2017) Cellular sites and mechanisms linking reduction of dipeptidyl peptidase-4 activity to control of incretin hormone action and glucose homeostasis

Tirzepatide carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2