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Heerspink HJL, Apperloo E, Davies M et al

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In the current review, we detail the ability of the gut microbiome to impact small intestinal nutrient-sensing mechanisms that activate a gutbrain neuronal axis to regulate hepatic glucose production

The American Diabetes Association and European Association for the study of Diabetes consensus guideline recommends that, in people with type 2 diabetes and established atherosclerotic cardiovascular disease, treatment for hyperglycaemia should be diet, lifestyle change and metformin, followed by, if this does not achieve target HbA 1c levels, an agent proven to reduce cardiovascular mortality risk (Davies, 2018)

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