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Statistical methods and details Mixed-model repeated-measures weight loss imputation A mixed model was run using SAS, including baseline weight, country, sex, prediabetes status, treatment, visit and the treatment-by-visit interaction as fixed effects, with a subject-level random effect

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Increases in glucagon from PG 100 mg/dL to nadir PG and during recovery from the nadir to 72 mg/dL did not differ between treatments (p=0.756 and p=0.565, respectively)

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Any rapid weight loss, including weight loss from a GLP-1 medication, can include some loss of muscle as well as fat

Tirzepatide: How They Work Although glucagon-like peptide 1 drugs (GLP-1s) may seem relatively new, theyve been around for over 15 years, with volumes of data to support their efficacy