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In summary, tirzepatide was noninferior and superior to semaglutide with respect to the reduction of HbA1c from baseline to 40 weeks (54, 71)

Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency

And it reduces lipogenesis, meaning the body creates less new fat from the food you eat

Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis

Is it possible we are missing a treatment effect of Lixisenatide because of the heterogeneity present in most Parkinsons groups recruited for clinical trials (in other words Parkinsons is not one disease and we may have recruited a few different subtypes and this watered down the potential effects)

& Schmidt, H