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Weight outcomes varied depending on why the medication was originally prescribed

Theres increasing interest in GLP-1 signaling for fatty liver disease and neurodegenerative disorders

In addition, because GLP-1 signaling is closely associated with glucose metabolism and gastrointestinal function, GLP-1R antagonism may have metabolic side effects, including hyperglycemia or altered insulin responses

doi: 10.2337/db09-0063 40 ArakawaMEbatoCMitaTHiroseTKawamoriRFujitaniYet al

Ferlay JLM, Ervik M et al

New drugs for the treatment of diabetes: part II: Incretin-based therapy and beyond