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Seattle, WA address on file

56 This may be the secret of the extraordinary efficacy of tirzepatide, but it is still possible that the best ratio of GLP-1 and GIP activity in a dual agonist has not been discovered

Baseline demographics and characteristics were well balanced between both groups

A further study presented at Digestive Disease Week 2025 of 993 patients found GLP-1RA to be associated with a statistically significant increase in clinical remission rates (HBI or Mayo score) at 3 months numerical at 6 and 12 months without an increase in side-effects

In this regard, DPP-4 resistant GLP-1 analogues including exenatide, liraglutide, albiglutide, dulaglutide are FDA approved and these analogues exhibit increased half-life