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Rothman RB, Baumann MH

Given these principally different modes of action, is it actually plausible that gutderived GLP1 should physiologically activate receptors within the CNS

GLP-1 Treatment Limitations: A Holistic Approach As effective as GLP-1s are in treating weight management, theyre not without drawbacksincluding high abandonment rates and substantial weight regain after treatment cessation

doi: 10.1016/j.ebiom.2025.105967

Common Side Effects Nausea Fullness Reduced appetite Constipation or diarrhea These typically improve with slow dose escalation

Therefore, DPP-4 inhibitors extend the half-life of endogenous GLP-1 lead to a 2threefold elevation of endogenous GLP-1 concentration, and provide beneficial effects in T2DM [110, 111]