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-hydroxybutyrate: a signaling metabolite

Co-agonist of glucagon and GLP-1 reduces cholesterol and improves insulin sensitivity independent of its effect on appetite and body weight in diet-induced obese C57 mice

doi: 10.1016/S0140-6736(06)69705-5 [DOI] [PubMed] [Google Scholar] 25.Rowlands J, Heng J, Newsholme P, et al

Research examined in the GLP-1 plays an important role in regulating blood sugar levels
Subtle differences with respect to interactions with the ECLsspecifically, the TM 6-ECL3-TM7/TM1have led to biased agonism (i.e., selective agonism of the cAMP signaling pathway)
The index date and the time of study entry were defined as the kidney transplant date, identified using ICD-10-CM code Z94.0 and relevant procedure codes
