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Big Number 21

Reddit posts show that a fourth 503B, Olympia Pharmaceuticals, officially exited the market in 2025

Continuous subcutaneous insulin infusion versus multiple daily insulin injections in type 2 diabetes: A meta-analysis
Approval is based on 2 RCTs, FIBRONEER-IPF & FIBRONEER-ILD, that show slowing of lung function decline IP & progressive pulmonary fibrosis (PPF) pts

One of the key differences is the dosages, with Wegovy having slightly higher doses, Daria Zajac, RD, LDN, reminds us

Researchers can use it to generate clean concentrationresponse relationships, evaluate second-messenger readouts such as cAMP in GLP-1 and GIP pathways, or examine glucagon-receptor engagement under predefined assay conditions
