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They tested thousands of different combinations of linkers, fatty acids along with changes the amino acid sequence leading to the development of semaglutide, an ultrastable receptor agonist in which a carboxylated fatty acid is coupled to lysine 26 via a hydrophilic linker (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Stefanou M.I., Theodorou A., Malhotra K., et al

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