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These efforts have led to the development of various GLP-1 receptor agonists, the most recent being semaglutide and tirzepatide, approved for the treatment of type 2 diabetes in 2018 and 2022, respectively

At month 1 they had weights for 12,909 patients which steadily declined until at at month 24 they only had a weight for 145 people (that is not a typo, they were doing the two year calculation upon which they drew their bold conclusions with only one hundred and forty five of the original 25k+ people represented!) This is such a bonkers way to do this that I actually emailed them, using the semaglutide table as an example, to make sure I was understanding this correctly

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If genuine tachyphylaxis is confirmed, strategies include dose escalation to the next tier, brief treatment breaks of 2 to 4 weeks to allow receptor resensitization, or switching to alternative GLP-1 agonists like semaglutide to provide different receptor activation patterns

Injection site reactions are common but usually mild

Sulfur Burps and Gas Sulfur burps burps that smell like rotten eggs are an indirect side effect of tirzepatide that many patients experience but few expect