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In addition to direct actions, pancreatic -cells can also be affected by paracrine actions that promote insulin production and release, thereby indirectly inhibiting glucagon secretion (Saltiel and Kahn, 2001

Diabet Med 33(11):15901597

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[DOI] [PubMed] [Google Scholar] 25.Cao M, Pan C, Tian Y, Wang L, Zhao Z, Zhu B

Orforglipron showed similar gastrointestinal side effects as other GLP-1 drugs, with the most common being diarrhea, nausea, indigestion, and constipation