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For many, that can include the need for a weekly subcutaneous injection

References Ahrn B (2015) Hepato-incretin function of GLP-1: novel concept and target in type 1 diabetes

By inhibiting osteoblast differentiation of VSMCs, GLP-1RAs can ameliorate phosphate-induced vascular calcification, which is mediated by the AMPK/mTOR pathway or AMPK/receptor activator of nuclear factor kappa B ligand (RANKL), as occurs in the osteoblast differentiation of VSMCs [128, 129]

Gastrointestinal hormones and the dialogue between gut and brain

Could GLP-1s curb cravings for things other than food

a Favor SGLT2 inhibitors or a GLP-1 receptor agonist over placebo