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modest caloric deficits are safer for the biliary system

Better energy, more muscle, leaner physique
42 , 43 Despite its favorable cost-effectiveness profile, tirzepatide may not be the best option for all patients

Long-Term Efficacy and Safety of Once-Weekly semaglutide for weight loss in patients without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Since B12 is found primarily in animal products, including meat, fish, dairy, and eggs, a substantial reduction in food intake can reduce B12 consumption below optimal levels, particularly for patients who were already borderline deficient before starting treatment or whose diets lean toward plant-based foods

The medication has been studied most prominently for managing blood sugar in patients with Type 2 diabetes, meaning some providers may only prescribe it for people with diabetes
