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Another placebo-controlled, phase-2 trial (NCT03987451) has been investigating the effectiveness of 2.4 mg of semaglutide in patients with NAFLD and cirrhosis for 48 weeks [130]

Follow-up measurements taken during the 90 days on either side of these post-index dates were valid, with the closest measurement to 180/365 days post-index used as the follow-up value if multiple measurements were available

Front Endocrinol (Lausanne) 3:158 Li Y, Tweedie D, Mattson MP et al (2010) Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells

BMI = 30.5 kg/m2 HBA1c = 7.5%

Addiction leads to absenteeism, incomplete assignments, and a decrease in overall academic achievement

Conclusions and Relevance These findings provide initial prospective evidence that low-dose semaglutide can reduce craving and some drinking outcomes, justifying larger clinical trials to evaluate GLP-1RAs for alcohol use disorder