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Safety and efficacy of exenatide once weekly plus dapagliflozin once daily versus exenatide or dapagliflozin alone in patients with type 2 diabetes inadequately controlled with metformin monotherapy: 52-week results of the DURATION-8 randomized controlled trial

Retatrutide, a next-generation triple-agonist peptide developed by Eli Lilly, offers a new approach by targeting GLP-1, GIP, and glucagon receptors simultaneously

Ozempic is used for type 2 diabetes
They may exist but are strongly discouraged by regulatory bodies like the Medicines and Healthcare products Regulatory Agency (MHRA)

During GLP-1 therapy, this synergy becomes critical because reduced caloric intake without structural support accelerates sarcopenia risk in older adults and those with sedentary baseline activity
